|
KMID : 0358419960390050946
|
|
Korean Journal of Obstetrics and Gynecology
1996 Volume.39 No. 5 p.946 ~ p.954
|
|
|
Expression of Glutathione S-transferase-π in Human Epithelial Ovarian Cancer as an Indicator of Resistance to Chemotherapy
|
|
서군석
우중배/조삼현/김경태/문형/황윤영/김완섭/박문향
|
|
|
Abstract
|
|
|
Expression of Glutathione S-transferase-π(GST-π) was examined immunohistochemically in relation to the response to chemotherapy with cisplatin in 80 patients with primary epithelial ovarian cancer who had not received any chemotherapy before
surgery.
To detect GST-π, the labeled streptavidin biotin method was used.
GST-π was positive(++/+++) in 46 patients(58%; 46/80), however GST-π was negative(-/+) in 34 patients(42%; 34/80). In the group of 37 patients with residual tumor, clinical response rate to the chemotherapy was significantly higher in GST-π
negative
patients(75%) than that of GST-π positive(16%)(p=0.0008). Second-look operation was performed in 35 patients during this period. Among 17 patients with second look positive (12) or recurred(5) cases, 13 patients(65%) were found in GST-π
positive
group, whereas 4 patients(27%) in negative group. In terms of pathological response rate to chemotharapy, in tend to increase durg resistant in the positive GST-π staining group(p=0.04). The5-year survival rate seemed to be shorter in the GST-π
positives group than that of GST-π negative(56% vs 66%). But it was not statistically significant.
Above data strongly suggest that GST-π expression in tumor cells seemed to be related with drug resistance of patients with epithelial ovarian cancer. However GST-π expression was not related with 5-yeasr survival rate. Further study will be
needed to
find relation between drug resistance and other factors including MDR, metallothionein.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|